Solid tumors become invasive if cells migrate away from their initial primary location. The tumor cell microenvironment with its variety of biomechanical and molecular cues plays a critical role in ...

In vivo, cancer cells exhibit invasion plasticity as they traverse extracellular matrix (ECM) barriers in collective or single-cell fashion while displaying either mesenchymal or amoeboid phenotypes.

Amoeboid migration is also used by metastatic cancer cells to aid their migration, dissemination and survival, whereby key mechanisms are hijacked from professionally motile immune cells. We explore ...

Cancer cells invade and travel along nerves in a process termed perineural invasion, which is a sign of aggressive disease. To better understand this process, a mouse model was used to select cancer ...

Amoeboid motility has come to refer to a spectrum of cell migration modes enabling a cell to move in the absence of strong, specific adhesion. To do so, cells have evolved a range of motile surface ...

Oestrogen receptor alpha (ERα) is a well-known target of endocrine therapy for ERα-positive breast cancer. ERα-negative cells, which are enriched during endocrine therapy, are associated with ...

Migration of cells in the developing brain is integral for the establishment of neural circuits and function of the central nervous system. While migration modes during which neurons employ ...

Amoeboid cell types are fundamental to animal biology and broadly distributed across animal diversity, but their evolutionary origin is unclear. The closest living relatives of animals, the ...

(PhysOrg.com) -- Takuya Umedachi has been working for several years to build a robot that can replicate the simple actions of the common slime mold, an organism that can move towards something it ...