Involution of the mammary gland is an essential process that removes the milk-producing epithelial cells when they become redundant at weaning. It is a two-step process that involves the death of the ...

Mammary gland involution is a period of intensive tissue remodeling. Over the course of a relatively brief period, a large proportion of the mammary gland epithelium undergoes programmed cell death ...

Taken together, a rate-limiting role of the BCL2 protein network in involution appears plausible, either as direct activator of mitochondrial apoptosis and/or as a modulator of LMP activity, as ...

Dry-off is one of the most important transitions in a dairy cow’s production cycle, yet there are relatively few ways to assess what is happening inside the mammary gland once milking stops. While ...

There is strong evidence that the pro-inflammatory microenvironment during post-partum mammary involution promotes parity-associated breast cancer. Estrogen exposure during mammary involution drives ...

In the United States, more than 1 million women every year have breast biopsies with benign findings and are thus diagnosed with benign breast disease. Our laboratory is defining features in breast ...

Many vertebrate organs are derived from monolayered epithelia that undergo morphogenesis to acquire their shape. Whereas asymmetric left/right gene expression within the zebrafish heart field has been ...