Journal of the Royal Statistical Society. Series B (Statistical Methodology), Vol. 79, No. 5 (NOVEMBER 2017), pp. 1439-1462 (24 pages) We propose a Bayesian decision theoretic model of a fully ...

Objective: The PPL, a class of statistics for complex trait genetic mapping in humans, utilizes Bayesian sequential updating to accumulate evidence for or against linkage across potentially ...

The customary approach to early-phase clinical trial design, where the focus is on identification of the maximum tolerated dose, is not always suitable for noncytotoxic or other targeted therapies.